University of California, San Diego | Skaggs School of Pharmacy and Pharmaceutical Sciences
HIGHLIGHTED PUBLICATIONS
Proteases for Neurotransmission and Neurodegenerative Diseases
Reviews: Proteases for Production of Peptides in Neurotransmission and Neurodegenerative Disease
Hook, V., Funkelstein, L., Lu, D., Bark, S., Wegrzyn, J., and Hwang, S.R. (2008) Proteases for processing proneuropeptides into peptide neurotransmitters and hormones. Annu. Rev. Pharmacol. Tox. 48, 393-423.
Hook, V. (2006)
Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease.
Biol. Chem. 387, 1429–1439.
Protease Pathways for Peptide Neurotransmitters: Endogenous Endorphin Peptides in Analgesia
Minokadeh, A., Funklestein, L., Toneff, T., Hwang, S.R., Reinheckel, T., Peters, C., Zadina, J., and Hook, V. (2010)
Cathepsin L participates in dynorphin neuropeptide production in brain cortex, illustrated by protease gene knockout and expression.
Molecular and Cellular Neuroscience 43, 98-107.
Funkelstein, L., Toneff, T., Hwang, S.R., Reinheckel, T., Peters, C., and Hook, V. (2008)
Major role of cathepsin L for producing ACTH, β-endorphin, and α-MSH peptide hormones derived from POMC, illustrated by gene knockout and expression.
J. Biol. Chem. 83, 35652-35659.
Hwang, S-R., Garza, C., Mosier, C., Toneff, T., Wunderlich, E., Goldsmith, P., and Hook, V. (2007)
Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion.
J. Biol. Chem. 282, 9556-9563.
Protease Drug Targets in Neurodegenerative Diseases: Alzheimer's Disease and Huntington's disease.
Hook, V., Hook, G., and Kindy, M. (2010)
Pharmacogenetic features of inhibitors to cathepsin B that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease.
Biological Chemistry 2010 Jun 11.
Hook, V., Kindy, M., and Hook, G. (2008)
Inhibitors of cathepsin B improve memory and reduce Ab in transgenic Alzheimer's disease mice expressing the wild type, but not the Swedish mutant, beta-secretase APP site.
J. Biol. Chem. 283, 7745-7753.
Mende-Mueller, L.M., Toneff, T., Hwang, S-R., Chesselet, M-F., and Hook, V.Y.H. (2001)
Tissue-specific proteolysis of huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.
J. Neurosci. 21, 1830–1837.
Proteomics and Peptidomics of Neurotransmitter-Producing Secretory Vesicles
Wegrzyn, J.L., Bark, S.J., Funkelstein, L., Mosier, C.A., Yap, A., Kazemi-Esfarjani, P., La Spada, J.L., Sigurdson, C., O'Connor, D.T., and Hook, V. (2010)
Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication.
J. Proteome Res. 2010 Aug 9.
Gupta, N., Bark, S.J., Lu, W.D., Taupenot, L., O'Connor, D.T., Pevzner, P., and Hook, V. (2010)
Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing.
J. Proteome Res. 2010 Aug 12.
Lortie, M., Bark, S., Blantz, R., and Hook, V. (2009)
Detecting low abundance vasoactive peptides in plasma: progress towards absolute quantitation using nano liquid chromatography – mass spectrometry.
Anal. Biochem. 394, 164-170.