University of California, San Diego | Skaggs School of Pharmacy and Pharmaceutical Sciences
CONTACT
Dr. Vivian Hook
Principal Investigator
Mailing Address:
9500 Gilman Drive #0744
La Jolla, CA 92093-0744
Telephone: 858-822-6682
Fax: 858-822-6681
E-mail: vhook@ucsd.edu
Thomas Drudge
Webmaster
Mailing Address:
9500 Gilman Drive #0744
La Jolla, CA 92093-0744
Telephone: 858-822-6695
Fax: 858-822-6696
E-mail: tdrudge@ucsd.edu
Staff Members
| Dr. Steven Bark | Associate Project Scientist |
| Dr. Lydiane Funkelstein | Postdoctoral Scholar |
| Dr. Doug Lu | Postdoctoral Scholar |
| Thomas Toneff | Senior Research Associate |
| Charles Mosier | Research Associate |
| Thomas Drudge | Computer Analyst |
| Gloria Sanchez | Laboratory Helper |
Student Members
| Ardalan Minokadeh | Graduate Student |
| Jill Wegrzyn | Graduate Student |
| Nitin Gupta | Graduate Student |
| Qi Ma | Graduate Student |
| Janet Lee | Medical Student |
| Julie Kim | Pharmacy Student |
| Lawrence Lau | Undergraduate Student |
| Jennifer O’Hara | Undergraduate Student |
Recent Publications:
Funkelstein L, Beinfeld M, Minokadeh A, Zadina J, Hook V. (2010)
Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides.
Neuropeptides 44, 457-66.
Hook V, Bark S, Gupta N, Lortie M, Lu WD, Bandeira N, Funkelstein L, Wegrzyn J, O'Connor DT, Pevzner P. (2010)
Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication.
AAPS J. 12, 635-45.
Gupta N, Bark SJ, Lu WD, Taupenot L, O'Connor DT, Pevzner P, Hook V. (2010)
Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing.
J Proteome Res. 9, 5065-75.
Highlighted Publications:
Hook, V., Funkelstein, L., Lu, D., Bark, S., Wegrzyn, J., and Hwang, S.R. (2008)
Proteases for processing proneuropeptides into peptide neurotransmitters and hormones.
Annu. Rev. Pharmacol. Tox. 48, 393-423.
Hwang, S-R., Garza, C., Mosier, C., Toneff, T., Wunderlich, E., Goldsmith, P., and Hook, V. (2007)
Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion.
J. Biol. Chem. 282, 9556-9563.