University of California, San Diego | Skaggs School of Pharmacy and Pharmaceutical Sciences
RESOURCES
Protease Pathways |
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| IPS - International Proteolysis Society | scientists working on all aspects of proteolytic enzymes, their substrates, and inhibitors |
| MEROPS database | peptidase and inhibitor database |
| UCSD Neuroscience Microscopy Facility at UCSD | Fluorescence Cell Imaging |
Enzymes: Biochemical Properties |
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| Brenda database | |
Mass Spectrometry |
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| Principals of Mass Spec Quantitation | Principals of Mass Spectrometry quantitation |
| Scripps Center for MS | providing analyses on a broad range of biological species from small molecules to large biological complexes |
Bioinformatics |
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| NCBI - National Center for Biotechnology Information | National Center for Biotechnology Information |
| Agilent - Spectrum Mill | Protein and peptide identification software |
| Thermo Finnigan - SEQUEST | Protein and peptide identification software |
| Matrix Sciences - MASCOT | Protein and peptide identification software |
Organizations and Education |
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| School of Medicine, UCSD | School of Medicine |
| School of Pharmacy, UCSD | School of Pharmacy |
| Neurosciences, UCSD | Neurosciences Department |
| SFN - Society for Neurosciences | Society for Neurosciences |
| HUPO - Human Proteome Organization | Human Proteome Organization |
| NIH - National Institutes of Health | National Institutes of Health |
Publications In Press:
Hook, V., Funkelstein, L., Lu, D., Bark, S., Wegrzyn, J., and Hwang, S.-R. (2007) Proteases for processing proneuropeptides into peptide neurotransmitters and hormones. Annu. Rev. Pharmacol. Tox.
Bark, S.J., and Hook, V. (2007) Differentical recovery of peptides from sample tubes and the reproducibility of quantitative proteomic data. J. Proteome Research.
Publications:
Hook, G., Hook, V.Y.H., and Kindy, M. (2007) Cysteine protease inhibitors reduce brain beta-amyloid and beta-secrease activity in vivo and are potential Alzheimer's disease therapeutics. Biol. Chem. 388, 979-983.
Hwang, S.R., and Hook, V.Y.H. (2007) Multiple domains of endopin 2A for serpin cross-class inhibition of papain. Arch. Biochem. Biophys. 46, 219-224.