University of California, San Diego | Skaggs School of Pharmacy and Pharmaceutical Sciences
RESOURCES
Protease Pathways |
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| IPS - International Proteolysis Society | scientists working on all aspects of proteolytic enzymes, their substrates, and inhibitors |
| MEROPS database | peptidase and inhibitor database |
| UCSD Neuroscience Microscopy Facility at UCSD | Fluorescence Cell Imaging |
Enzymes: Biochemical Properties |
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| Brenda database | |
Mass Spectrometry |
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| Principals of Mass Spec Quantitation | Principals of Mass Spectrometry quantitation |
| Scripps Center for MS | providing analyses on a broad range of biological species from small molecules to large biological complexes |
Bioinformatics |
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| NCBI - National Center for Biotechnology Information | National Center for Biotechnology Information |
| Agilent - Spectrum Mill | Protein and peptide identification software |
| Thermo Finnigan - SEQUEST | Protein and peptide identification software |
| Matrix Sciences - MASCOT | Protein and peptide identification software |
Organizations and Education |
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| School of Medicine, UCSD | School of Medicine |
| School of Pharmacy, UCSD | School of Pharmacy |
| Neurosciences, UCSD | Neurosciences Department |
| SFN - Society for Neurosciences | Society for Neurosciences |
| HUPO - Human Proteome Organization | Human Proteome Organization |
| NIH - National Institutes of Health | National Institutes of Health |
Recent Publications:
Funkelstein L, Beinfeld M, Minokadeh A, Zadina J, Hook V. (2010)
Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides.
Neuropeptides 44, 457-66.
Hook V, Bark S, Gupta N, Lortie M, Lu WD, Bandeira N, Funkelstein L, Wegrzyn J, O'Connor DT, Pevzner P. (2010)
Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication.
AAPS J. 12, 635-45.
Gupta N, Bark SJ, Lu WD, Taupenot L, O'Connor DT, Pevzner P, Hook V. (2010)
Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing.
J Proteome Res. 9, 5065-75.
Highlighted Publications:
Hook, V., Funkelstein, L., Lu, D., Bark, S., Wegrzyn, J., and Hwang, S.R. (2008)
Proteases for processing proneuropeptides into peptide neurotransmitters and hormones.
Annu. Rev. Pharmacol. Tox. 48, 393-423.
Hwang, S-R., Garza, C., Mosier, C., Toneff, T., Wunderlich, E., Goldsmith, P., and Hook, V. (2007)
Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion.
J. Biol. Chem. 282, 9556-9563.