The Skaggs School of Pharmacy & Pharmaceutical Sciences

Palmer Taylor

Dr. Palmer Taylor received his Ph.D. degree in 1964 From the University of Wisconsin. He is currently the Associate Vice Chancellor for Health Sciences, the Endowed Chair in Pharmacology and the Dean for the Skaggs School of Pharmacy and Pharmaceutical Sciences.

Research Interests

Dr. Palmer Taylor's research has been directed to the structures, recognition capacities and regulation of expression of proteins governing neurotransmission in cholinergic synapses. His group cloned the first acetylcholinesterase (AChE) gene over 20 years ago, and this was followed by analysis of its genomic DNA to delineate regulatory regions, the multiple splicing options and gene expression profiles in nerve and muscle. His studies of AChE structure and its complexes by crystallographic and fluorescence methods, characterizing a peripheral site on AChE and the demonstrating flexibility of the active center gorge, provided the basis for collaborative studies with Barry Sharpless' group employing freeze-frame, click chemistry. The very biological target itself (AChE) is used as the template in the synthesis of high affinity, selective inhibitors. Taylor's long standing work with nicotinic acetylcholine receptors (nAChR) defined ligand specificity in relation to state functions for receptor activation and desensitization and identified the structural determinants on nAChR governing ligand and peptide toxin specificity. More recently, his studies have been directed to the acetylcholine binding protein, a soluble surrogate of the receptor, whereby his group in collaboration with others, employed physical methods of fluorescence anisotropy decay, NMR, x-ray crystallography and denterium hydrogen exchange to examine structure and selectivity of the ligand binding sites. Finally, through collaborative endeavors, Taylor's group have uncovered much of what is known about the structure of neuroligin, a synaptic adhesion molecule homologous to AChE. Their structural studies on neuroligin have uncovered alterations in processing and folding associated with mutations found in the autistic spectral disorders.

Selected Publications

Talley, T.T., Yalda, S., Ho, K-Y, Tor, Y., Soti, F.S., Kem, W.R. and Taylor, P. Spectroscopic Analysis of Benzylidene Anabaseine Complexes with Acetylcholine Binding Proteins as Models for Ligand-Nicotinic Receptor Interactions. Biochemistry, 45:8894-8902 (2006).

Comoletti, D., Flynn, R.E., Boucard, A.A., Demeler, B., Schirf, V., Shi, J., Jennings, L.L., Newlin, H.R., Südhof, T.C. and Taylor, P. Gene Selection, Alternative Splicing, and Post-translational Processing Regulate Neuroligin Selectivity for ß-Neurexins. Biochemistry, 45:12816-12827 (2006).

Hansen, S.B. and Taylor, P. Galanthamine and Non-competitive Inhibitor Binding to Ach-binding Protein: Evidence for a Binding Site on Non a-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors. J. Mol.Biol., 369:895-901 (2007).

Comoletti, D., Grishaev, A., Whitten, E. A, Tsigelny, I., Taylor, P. and Trewhella, J. Synaptic Arrangement of the Neuroligin/ß-Neurexin Complex Revealed by X-ray and Neutron Scattering. Structure., 15:693-705 (2007), Cover Article.

Camp, S., De Jaco, A., Zhang, L., Marquez, M., De Lar Torre, B., and Taylor, P. Acetylcholinesterase Expression in Muscle is Specifically Controlled by a Promoter-Selective Enhancesome. J. Neuroscience (2007). Accepted for Publication.

List of Publications in Pub Med