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Dr. David N. Bailey
Analytical Toxicology; Drug Binding; Drug Metabolism
David N. Bailey, M.D.
Distinguished Research Professor of Pathology and Pharmacy
Deputy Dean, Skaggs School of Pharmacy and Pharmaceutical Sciences
Vice Chair for Education and Academic Affairs (Pathology)
Research Summary: Analytical Toxicology, Drug Binding, and Drug Metabolism
Dr. Bailey's research has focused on development of analytical methodology for measuring drugs and drug metabolites; on the binding of drugs to human tissues; and on the percutaneous absorption of drugs with particular emphasis on psychotropic drugs and drugs of abuse.
B.S in Chemistry (1967) Indiana University; M.D. (1973) Yale; Postdoctoral Fellow (1973-1975) and Resident (1975-1977) Yale.
Chair, Dept. of Pathology UCSD (1986-2001); Interim Vice Chancellor for Health Sciences and Dean, School of Medicine UCSD (1999-2000 and 2006-07); Deputy Vice Chancellor for Health Sciences and Dean, Faculty and Student Matters UCSD (2001-2006); Vice Chancellor for Health Affairs and Dean, School of Medicine UCI (2007-2009); Deputy Dean, Skaggs School of Pharmacy & Pharm. Sci. UCSD (2010 – present); Vice Chair for Education and Academic Affairs (Pathology) UCSD (2010 - present); President, California Association of Toxicologists (1981-1982); President, Academy of Clinical Laboratory Physicians & Scientists (1988-1989); Secretary-Treasurer (1996-1999) and Senior Fellow (2015-Present), Association of Pathology Chairs (1996-1999).
Key Contributions to Pharmaceutical Sciences
- Reported the binding of cocaethylene and other cocaine homologs to human serum proteins and tissues
- Reported serum concentrations and developed profiles of toxicity related to drug concentrations for a number of psychotropic drugs in various patient populations
- Reported percutaneous absorption of a number of drugs of abuse
Selected Recent Publications (from more than 100 peer-reviewed articles)
- Bailey et al (1985). Effect of parenterally administered atropine on the percutaneous absorption of phencyclidine and methadone. Life Sci. 37:417-23.
- Bailey et al. (1989). Cocaine-and methamphetamine-related deaths in San Diego County (1987): homicides and accidental overdoses. J. Forensic Sci. 34:407-22.
- Bailey et al. (1990). Detection of isopropanol in acetonomic patients not exposed to isopropanol. J. Toxicol Clin. Toxicol. 28:459-466.
- Bailey et al. (1992). Interaction of tricyclic antidepressants with cholestyramine in vitro. Ther. Drug Monit. 14:339-342.
- Bailey (1995). Cocapropylene (propylcocaine) formation by human liver in vitro. J Anal Toxicol. 19: 1-4.
- Bailey (1996). Comprehensive review of cocaethylene and cocaine concentrations in patients. Am. J. Clin. Pathol. 106:701-706.
- Bailey (1997). Cocaine and cocaethylene binding to human placenta in vitro. Am. J. Obstet. Gynecol. 177: 527-531.
- Bailey et al (2003). Procainamide and quinidine inhibition of the human hepatic degradation of meperidine in vitro. J. Anal. Toxicol. 27:142-144.
- Bailey et al (2005). Studies of the inhibition of human pseudocholinesterase activity in vitro by commonly used drugs. Am. J. Clin. Pathol. 124:226-228.
- Bailey et al (2005). The effect of lovastatin and thioridazine on the degradation of cocaine in human serum in vitro. Ther. Drug Monit. 27:168-170.
- Bailey et al (2016). Life after being a pathology department chair: issues and opportunities.. Acad. Pathol. Volume 3:1-8.