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External Resources:

Dr. Dong Wang

Transcription, Epigenetics, DNA Damage and Repair, Chemotherapy

Dong Wang

Dong Wang, Ph.D.

Associate Professor
Skaggs School of Pharmacy and Pharmaceutical Sciences

Email
dongwang@ucsd.edu

Phone
(858) 822-5561

Lab Website
http://pharmacy.ucsd.edu/labs/wang/


Research Summary: Transcription, Epigenetics, DNA Damage and Repair, Chemotherapy

Dr. Wang’s research focuses on understanding transcription and epigenetic regulation, chromatin dynamics, DNA damage repair, as well as developing novel anticancer drugs.

Dr. Wang’s group takes a multidisciplinary approach, combining structural biology, chemical biology, biochemistry, computational biology, and genetic methods, to study key protein complexes involved in these fundamental processes and pathways. Understanding how cell process these DNA lesions will help us to understand the mechanisms of drug action and resistance and pave the way for rational improvement of novel anticancer drugs. 

Academic Achievements

Education:

B.Sc. in Chemistry (1998) Peking University; Ph. D. in Biological Chemistry (2004) Massachusetts Institute of T echnology; Postdoc Fellow in Structural Biology at Stanford University School of Medicine (2009). 

Awards and Honors:

OKeanos-CAPA Young Investigator Award at the Chemical and Biology Interface (2015); Kimmel Scholar Award (2012); UCSD Academic Senate Research Grant Award (2010); CIBA Young Scientist Award (2010); NIH Pathway to Independence Award (K99/R00, 2008); Leukemia & Lymphoma Society Career Development Program Special Fellow Award (2007); ASBMB Travel Award (2007&2008); ASBMB Chromosome Cycle Theme Poster Award (2007); Anna Fuller Fund Graduate Fellowship (2002). 

Leadership Experience:

Executive committee member, Stanford University Postdoc Association (2007-2008); Executive council member, Chinese-American Biopharmaceutical Society (2007-2008); Co-Chair, Chinese Life Sciences Postdocs and Students at Stanford (2005-2007). 

Teaching

  • Pharmaceutical Chemistry I (SPPS 221)
  • Pharmaceutical Chemistry III (SPPS 223)
  • Concepts in Pharmacy Practice (SSPPS 202A)
  • CTIPS (SPPS218B)
  • Macromolecular Recognition (Chem 209)
  • Chemical Biology (Chem 216)

Key Contributions to Pharmaceutical Sciences

  • Investigate the action and resistance mechanisms of platinum anticancer agents.
  • Structural studies of transcription inhibition by a variety of anticancer agents.

Selected Recent Publications (view more)