The Skaggs School of Pharmacy & Pharmaceutical Sciences

Bradley Moore

Dr. Brad Moore has a joint appointment with the Skaggs School of Pharmacy and Pharmaceutical Sciences and Scripps Institution of Oceanography, as Professor. Dr. Moore received his Ph.D. in Bioorganic Chemistry from the University of Washington in 1994. His research is focused on developing new technologies to genetically engineer pharmaceutically relevant bacterial natural products and their derivatives for drug discovery and development.

Research Interests

Biosynthesis of marine microbial natural products, combinatorial biosynthesis, in vitro and in vivo biochemical analysis of biosynthetic enzymes, directed and random approaches toward enzyme engineering, chemoenzymatic synthesis, accessing the biosynthetic potential of uncultured bacteria associated with marine invertebrates, microbial genomics, drug discovery

Selected Publications

J. M. Winter, M. C. Moffitt, E. Zazopoulos, J. B. McAlpine, P. C. Dorrestein, and B. S. Moore, "Molecular basis for chloronium-mediated meroterpene cyclization: Cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster", J. Biol. Chem., 282, 16362-16368 (2007).

D. W. Udwary, L. Zeigler, R. Asolkar, V. Singan, A. Lapidus, W. Fenical, P. R. Jensen, and B. S. Moore, "Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica", Proc. Natl. Acad. Sci. USA, 104, 10376-10381 (2007).

Q. Cheng, L. Xiang, M. Izumikawa, D. Meluzzi, and B. S. Moore, "Enzymatic total synthesis of enterocin polyketides", Nat. Chem. Biol., 3, 557-558 (2007).

A. S. Eustáquio, F. Pojer, J. P. Noel, and B. S. Moore, "Discovery and characterization of a marine bacterial SAM-dependent chlorinase", Nat. Chem. Biol., 4, 69-74 (2008).

R. P. McGlinchey, M. Nett, and B. S. Moore, "Unraveling the biosynthesis of the sporolide cyclohexenone building block", J. Am. Chem. Soc., 130, 2406-2407 (2008).

List of Publications in Pub Med