Structure of RNA Pol II
Elongation Complex.
Pyriplatin Blocks RNA
Pol II Transcription.
Structure of RNA Pol II
Backtracked Complex.
Mechanism of RNA Pol II
Transcription Fidelity.
Interdisciplinary Research
Approaches in Wang Lab

 

About

Dr. Wang's research focuses on understanding the mechanisms of cellular responses to DNA damage, particularly the functional interplay between transcription and epigenetic DNA modifications and lesions. His group takes a multidisciplinary approach, combining structural biology, chemical biology, computational biology, biochemical, and genetic methods, to study key protein complexes involved in these processing pathways. The results will have implications for DNA damage recognition and DNA repair. Moreover, understanding how cells process these DNA lesions will help us to decipher the mechanisms of drug action and resistance and pave the way for rational improvement of novel anticancer drugs.

More About the Wang Lab

 

News

  • November 7, 2016 - Congratulations to Ji for her success in thesis defense!
  • November 1, 2016 - Congratulations to Liang, Wei, Jenny and Ji for their work in understanding how RNA pol II senses non-covlaent minor groove barriers via a conserved motif. The work was recently published in Proc. Natl. Acad. Sci. USA.
  • March 24, 2016 - Congratulations to Liang, Wei, Jenny and Ji for their work in understanding the functional interplay between NTP leaving group and base pair recognition during pol II transcription accepted by Nucleic Acids Res.
  • March 14, 2016 - Congratulations to Liang! Our collaborative work related to pol II backtracking mechanism is accepted by Nat. Comm.
    Congratulations to Ji and Liang for our point-of-view paper suggesting pol II acts as a selective sensor for DNA lesions and endogenous DNA modifications is accepted by Transcription.
  • June 29, 2015 - Our research paper entitled "Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex" was published online at Nature. Congratulations to everyone!
  • June 4, 2015 - Congratulations to Dr. Wang, who has been selected as the recipient of the 2015 OKeanos-CAPA Young Investigator Award at the Chemical and Biology interface!
  • January 16, 2015 - Congratulations to Liang, Wei and Jenny for their paper on elucidating the impacts of template heterogeneity on transcription being recently accepted by Nucleic Acids Res. Great work!
  • January 8, 2015 - Happy New Year! Congratulations to Lanfeng and Jenny for their second paper on elucidating the mechanism of transcriptional translesion bypass being recently accepted by Proc. Natl. Acad. Sci. USA. (on December 22, 2014).  A great start to a new year!
  • November 26, 2014 - Congratulations to Lanfeng and Jenny for their paper being accepted by Proc. Natl. Acad. Sci. USA and Happy Thanksgiving!
  • Aug. 27, 2014 - Our research paper entitled "Pyrene-Based Quantitative Detection of the 5-Formylcytosine Loci Symmetry in the CpG Duplex Content during TET-Dependent Demethylation" was published online at Angew. Chem. Int. Ed. Engl. Congratulations to Liang, Jenny, and Jun. Way to go!
  • July 29, 2014 - Our research paper entitled “Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity” was published online at Proc. Natl. Acad. Sci. USA. This is the "grand finale" of our “scientific trilogy” of “chemical perspectives on Pol II transcriptional fidelity” along with Kellinger et al J. Am. Chem. Soc. (2012) and Xu et al Angew. Chem. Int. Ed. Engl. (2013). Congratulations to Liang, Jenny, and Jun for excellent work!
  • April 28, 2014 - Our paper in collaboration with Dr. Changsun Eun and Prof. J. Andrew McCammon on TFIIS conformational change was accepted by PLoS One. Congratulations!
  • March 27, 2014 - Our collaborative paper with Prof. Xuhui Huang on Pol II translocation was accepted by Proc. Natl. Acad. Sci. USA. Well done!
  • March 10, 2014 - Congratulations to Liang and Jenny for another paper accepted by Nucleic Acids Res.!  Great work!
  • More News

Positions Available

Postdoc, Graduate, and Volunteer Positions

We are looking for a highly motivated postdoctoral research fellow and students to join our laboratory.

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Contact

The Wang Group

9500 Gilman Drive, PSB 2171, MC 0625
La Jolla, CA 92093-0625
Phone: (858) 822-0110
Fax: (858) 822-1953

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