Structure of RNA Pol II
Elongation Complex.
Pyriplatin Blocks RNA
Pol II Transcription.
Structure of RNA Pol II
Backtracked Complex.
Mechanism of RNA Pol II
Transcription Fidelity.
Interdisciplinary Research
Approaches in Wang Lab

About

Dr. Wang's research focuses on understanding the mechanisms of cellular responses to DNA damage. His group takes a multidisciplinary approach, combining structural biology, biochemical, and genetic methods, to study key protein complexes involved in these processing pathways. The results will have implications for DNA damage recognition and DNA repair. Moreover, understanding how cells process these DNA lesions will help us to decipher the mechanisms of drug action and resistance and pave the way for rational improvement of novel anticancer drugs.

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News

  • July 1, 2010 - UCSD Academic Senate Research Grant
  • May 25, 2010 - Our research paper titled “structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct” was published on PNAS
  • May 18, 2010 - Baby girl Alice Wang was born
  • Feb 22, 2010 - Wang Lab’s first synchrotron data collection at ALS
  • Feb 2010 - Welcome aboard, Justine and Pei Chi (undergraduate)
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Positions Available

Postdoc Position

We are looking for a highly motivated postdoctoral research fellow to join our laboratory.

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Contact

The Wang Group

9500 Gilman Drive, PSB 2171, MC 0625
La Jolla, CA 92093-0625
Phone: (858) 822-0110
Fax: (858) 822-1953

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