PALMER TAYLOR SYMPOSIUM: PROGRAM

WELCOME (James McKerrow, Dean, Skaggs School of Pharmacy and Pharmaceutical Sciences and Associate Vice Chancellor for Health Sciences, UC San Diego; Pradeep Khosla, Chancellor, UC San Diego)

RECEPTORS (Bill Catterall, Professor and Chair, Department of Pharmacology, University of Washington; Andy McCammon, Distinguished Professor of Chemistry and Biochemistry, UC San Diego; Chairs) (8:45 AM – 11:45 AM)

"Voltage-Gated Sodium and Calcium Channels at Atomic Resolution"
Bill Catterall, Professor and Chair, Department of Pharmacology, University of Washington

"Molecular Recognition Linked to Biological Function in Nicotinic Receptors"
Steven Sine, Professor, Department of Physiology, Mayo Clinic

"Structural Biology of Nicotinic Acetylcholine Receptors"
Ryan Hibbs, Assistant Professor, Department of Biophysics and Neuroscience, University of Texas (Southwestern)

REFRESHMENT BREAK

"Allosteric Transition of the Pentameric Ligand-Gated Ion Channel"
Pierre-Jean Corringer, Research Director and Head, Channel-Receptor Unit, Pasteur Institute

"Lipid-Gated Ion Channels and Their Roles in General Anesthesia and Mechanosensation"
Scott Hansen, Assistant Professor, Department of Molecular Therapeutics and Neuroscience, The Scripps Research Institute

"The Biogenesis and Trafficking of Acetylcholinesterase: From Basic Cell Biology to Therapeutic Applications"
Richard Rotundo, Professor of Cell Biology and Anatomy, University of Miami

BOX LUNCH

WELCOME (Richard Atkinson, University of California President Emeritus)

TOXINS AND NATURAL PRODUCTS (William Gerwick, Distinguished Professor, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego; Barry Sharpless, W.M. Keck Professor of Chemistry, The Scripps Research Institute; Chairs) (1:30 PM – 4:30 PM)

"Structural and Functional Studies on the Reversible and Irreversible Inhibition of Acetylcholinesterase"
Gabriel Amitai, Bernstein-Mason Professorial Chair of Neurochemistry, Weizmann Institute of Science

"The Rapid and Evolving World of Natural Products Science and Its Impact on Human Health"
Brad Moore, Professor, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego

"Common Determinants in Natural Toxins and Non-Toxin Molecules to Recognize ACh-Binding Macromolecules"
Pascale Marchot, Senior Researcher & Team Leader, AFMB Lab, Centre National de la Recherche Scientifique / Aix-Marseille Université, Marseille

REFRESHMENT BREAK

"Acetylcholinesterase: 25 Years Since the 3D Structure Was Solved – What Have We Learned?"
Joel Sussman, Professor, Department of Structural Biology, Weizmann Institute of Science

"Discovery and Development of Therapeutic Leads from Toxic Marine Cyanobacterial Natural Products"
William Gerwick, Distinguished Professor, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego

COCKTAIL RECEPTION (ESTANCIA HOTEL)

WELCOME (Charlene Zettel, UC Regent)

PHARMACOLOGY (Paul Insel, Professor, Department of Pharmacology, UC San Diego; Andy McCammon, Distinguished Professor of Chemistry and Biochemistry, UC San Diego; Chairs) (8:45 AM – 11:45 AM)

"Neurotransmitter Transporters and the Cellular Actions of Amphetamines: A Walk on the Presynaptic Side"
Susan Amara, Scientific Director, National Institute of Mental Health

"Human Genomics and the Future of Medicine"
Craig Venter, Founder, Chairman, and Chief Executive Officer, J. Craig Venter Institute and HLI - Co-Founder, Executive Chairman, CEO

"Novel Targets for GPCR- and RhoA-medicated Pathophysiological Responses"
Joan Heller-Brown, Professor and Chair, Department of Pharmacology, UC San Diego

REFRESHMENT BREAK

"GPCR Expression in Health and Disease: Using Lessons from Palmer Taylor"
Paul Insel, Professor, Department of Pharmacology, UC San Diego

"GPCR Allostery and Drug Discovery" 
Arthur Christopoulos, Professor, Department of Pharmacology, Monash

"Synaptic Connectivity: Molecular Aspects and Implications in Neurodevelopmental Disorders"
Davide Comoletti, Assistant Professor of Neurosciences and Cell Biology and Pediatrics, Child Health Institute of New Jersey, Rutgers University

BOX LUNCH

WELCOME (David Brenner, Vice Chancellor for Health Sciences and Dean, School of Medicine, UC San Diego)

CHEMISTRY (Pieter Dorrestein, Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego; Tracy Handel, Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego) (1:30 PM – 4:30 PM)

"The Art of Falling Apart: Controlling Polymer Degradation for Health Sciences and Medicine"
Adah Almutairi, Associate Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego

"Molecules for Long-Term Memory Storage"
Roger Tsien, Distinguished Professor, Department of Chemistry and Biochemistry, UC San Diego

"Digitizing the Chemistry of Microbes and People through Molecular 3D Cartography"
Pieter Dorrestein, Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego

REFRESHMENT BREAK

"Click Chemistry: New Directions"
Barry Sharpless, W.M. Keck Professor, Department of Chemistry, The Scripps Research Institute

"Molecular Dynamics and Drug Discovery"
Andy McCammon, Distinguished Professor, Department of Chemistry and Biochemistry, UC San Diego