Dr. David N. Bailey

Analytical Toxicology; Drug Binding; Drug Metabolism

David N. Bailey, M.D.

Distinguished Research Professor (Pathology and Pharmacy)
Emeritus Professor of Pathology
Deputy Dean, Skaggs School of Pharmacy and Pharmaceutical Sciences
Vice Chair for Education (Pathology)
Telephone: (858) 822-5551
Email: dnbailey@ucsd.edu

Research Summary: Analytical Toxicology, Drug Binding, and Drug Metabolism

Dr. Bailey's research has focused on development of analytical methodology for measuring drugs and drug metabolites; on the binding of drugs to human tissues; and on the percutaneous absorption of drugs with particular emphasis on psychotropic drugs and drugs of abuse.

Academic Achievements

Education: B.S in Chemistry (1967) Indiana University; M.D. (1973) Yale; Postdoctoral Fellow (1973-1975) and Resident (1975-1977) Yale.
Leadership Experience: Chair, Dept. of Pathology UCSD (1986-2001); Interim Vice Chancellor for Health Sciences and Dean, School of Medicine UCSD (1999-2000 and 2006-07); Deputy Vice Chancellor for Health Sciences and Dean, Faculty and Student Matters UCSD (2001-2006); Vice Chancellor for Health Affairs and Dean, School of Medicine UCI (2007-2009); Deputy Dean, Skaggs School of Pharmacy & Pharm. Sci. UCSD (2010 – present); Vice Chair for Education (Pathology) UCSD (2010 - present); President, California Association of Toxicologists (1981-1982); President, Academy of Clinical Laboratory Physicians & Scientists (1988-1989); Secretary-Treasurer, Association of Pathology Chairs (1996-1999).

Teaching

* Clinical pathology (Laboratory Medicine) lectures, laboratories, and seminars, for medical students
* Clinical pathology lectures and conferences for pathology residents

Key Contributions to Pharmaceutical Sciences

* Reported the binding of cocaethylene and other cocaine homologs to human serum proteins and tissues
* Reported serum concentrations and developed profiles of toxicity related to drug concentrations for a number of psychotropic drugs in various patient populations

Selected Recent Publications

(PubMed List)
Bailey et al (1985). Effect of parenterally administered atropine on the percutaneous absorption of phencyclidine and methadone. Life Sci. 37:417-23.
Bailey et al. (1989). Cocaine-and methamphetamine-related deaths in San Diego County (1987): homicides and accidental overdoses. J. Forensic Sci. 34:407-22.
Bailey et al. (1990). Detection of isopropanol in acetonomic patients not exposed to isopropanol. J. Toxicol Clin. Toxicol. 28:459-466.
Bailey et al. (1992). Interaction of tricyclic antidepressants with cholestyramine in vitro. Ther. Drug Monit. 14:339-342.
Bailey (1993). Serial plasma concentrations of cocaethylene, cocaine, and ethanol in trauma victims. J. Anal Toxicol. 17:79-83.
Bailey (1995). Cocapropylene (propylcocaine) formation by human liver in vitro. J Anal Toxicol. 19: 1-4.
Bailey (1996). Comprehensive review of cocaethylene and cocaine concentrations in patients. Am. J. Clin. Pathol. 106:701-706.
Bailey (1997). Cocaine and cocaethylene binding to human placenta in vitro. Am. J. Obstet. Gynecol. 177: 527-531.
Bailey et al (2003). Procainamide and quinidine inhibition of the human hepatic degradation of meperidine in vitro. J. Anal. Toxicol. 27:142-144.
Bailey et al (2005). Studies of the inhibition of human pseudocholinesterase activity in vitro by commonly used drugs. Am. J. Clin. Pathol. 124:226-228.
Bailey et al (2005). The effect of lovastatin and thioridazine on the degradation of cocaine in human serum in vitro. Ther. Drug Monit. 27:168-170.