Structure of RNA Pol II
Elongation Complex.
Pyriplatin Blocks RNA
Pol II Transcription.
Structure of RNA Pol II
Backtracked Complex.
Mechanism of RNA Pol II
Transcription Fidelity.
Interdisciplinary Research
Approaches in Wang Lab



Dr. Wang's research focuses on understanding the mechanisms of cellular responses to DNA damage, particularly the functional interplay between transcription and epigenetic DNA modifications and lesions. His group takes a multidisciplinary approach, combining structural biology, chemical biology, computational biology, biochemical, and genetic methods, to study key protein complexes involved in these processing pathways. The results will have implications for DNA damage recognition and DNA repair. Moreover, understanding how cells process these DNA lesions will help us to decipher the mechanisms of drug action and resistance and pave the way for rational improvement of novel anticancer drugs.

More About the Wang Lab



  • March 1, 2018 - Welcome aboard, Juntaek Oh (Post-doc)!
  • February 2, 2018 - Congratulations to Wei and Jenny for their work elucidating the structural basis of transcriptional stalling and bypass of abasic DNA lesion is accepted by Proc. Natl. Acad. Sci. U.S.A.
  • November 30, 2017 - Congratulations, Jun, Wei and Jenny for their paper titled “Structural basis for the initiation of eukaryotic transcription-coupled DNA repair” is published in Nature.
  • September 25, 2017 - Congratulations to Jenny for her new position in the industry. All the best to her new career!
  • September 21, 2017 - Congratulations to Wei, Liang, and Jenny for their work in understanding how RNA pol II senses 6-meA modifications. The work was recently published in J. Am. Chem. Soc.

Positions Available

Postdoc, Graduate, and Volunteer Positions

We are looking for a highly motivated postdoctoral research fellow and students to join our laboratory.

More Positions Available


The Wang Group

9500 Gilman Drive, PSB 2171, MC 0625
La Jolla, CA 92093-0625
Phone: (858) 822-0110
Fax: (858) 822-1953

More Contact Information