University of California, San Diego | Skaggs School of Pharmacy and Pharmaceutical Sciences
CONTACT
Dr. Vivian Hook
Distinguished Professor
Mailing Address:
9500 Gilman Drive MC0657
La Jolla, CA 92093-0657
Telephone: 858-822-6682
Fax: 858-822-6681
E-mail: vhook@ucsd.edu
Jill Wegrzyn
Webmaster
Mailing Address:
9500 Gilman Drive #0744
La Jolla, CA 92093-0744
Telephone: 858-822-6695
Fax: 858-822-6696
E-mail: jwegrzyn@ucsd.edu
Members
| Sonia Podvin | Project scientist | ||
| Charles Mosier | Staff research associate | ||
| Michael Yoon | PharmD/PhD student | ||
| Von Phan | PharmD/PhD student | ||
| Diego Trujillo | PhD student | ||
| Laura Seyffert | MS student | ||
| Enlin Wei | MS student | ||
| Ben Boyarko | Student | ||
| Gen Ito | Lab Assistant | ||
| Charisse Winston | Postdoctoral Scholar | ||
| Nicole Avalon | Postdoctoral Scholar | ||
| Graduate Student Research Rotations - Summer Research Internships | |||
| Undergraduate Research, Independent Study | |||
| Visiting Students and Scientists | |||
Recent Publications:
Hook, V., Yoon, M., Mosier, C., Ito, G., Podvin, S., Head, B.P., Rissman, R., O'Donoghue, A.J., Hook, G. (2020) Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 1868, 140428.
Boutté, A.M., Hook, V., Thangavelu, B., Sarkis, G.A., Abbatiello, B.N., Hook, G., Jacobsen, J.S., Robertson, C.S., Gilsdorf, J., Yang, Z., Wang, K.K.W., Shear, D.A. (2020) Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid. J Neurotrauma 37(13),1574-1586.
Podvin, S., Jones, A., Liu, Q., Aulston, B., Ransom, L., Ames, J., Shen, G., Lietz, C.B., Jiang, Z., O'Donoghue, A.J., Winston, C., Ikezu, T., Rissman, R.A., Yuan, S., Hook, V. (2020) Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics 9, 1017-1034.
Yoon, M.C., Solania, A., Jiang, Z., Christy, M.P., Podvin, S., Mosier, C., Lietz, C.B., Ito, G., Gerwick, W.H., Wolan, D.W., Hook, G., O'Donoghue, A.J., Hook, V. (2021) Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions. ACS Chem Biol. 16, 1628-1643.
Jiang, Z., Lietz, C.B., Podvin, S., Yoon, M.C., Toneff, T., Hook, V., O'Donoghue, A.J. (2021) Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing. ACS Chem Neurosci. 12, 2385-2398.
Campeau, A., Mills, R.H., Stevens, T., Rossitto, L.A., Meehan, M., Dorrestein, P., Daly, R., Nguyen, T.T., Gonzalez, D.J., Jeste, D.V., Hook V. (2021) Multi-omics of Human Plasma Reveals Molecular Features of Dysregulated Inflammation and Accelerated Aging in Schizophrenia. Molecular Psychiatry Nature 2021 Nov 5.
Podvin, S., Jones, A., Liu, Q., Aulston, B., Mosier, C., Ames, J., Winston, C., Lietz, C.B., Jiang, Z., O'Donoghue, A.J., Ikezu, T., Rissman, R.A., Yuan, S.H., Hook, V. (2021) Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS Omega 6(20), 13033-13056.
Boyarko, B., Hook, V. (2021) Human tau isoforms and proteolysis for production of toxic tau fragments in neurodegeneration. Frontiers in Neuroscience 15, 1-19.
Ashhurst, A.S., Tang, A.H., Fajtová, P., Yoon, M.C., Aggarwal, A., Bedding, M.J., Stoye, A., Beretta, L., Pwee, D., Drelich, A., Skinner, D., Li, L., Meek, T.D., McKerrow, J.H., Hook, V., Tseng, C.T., Larance, M., Turville, S., Gerwick, W.H., O'Donoghue, A.J., Payne, R.J. (2021) Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. J Med Chem. 2021 Nov 3