University of California, San Diego | Skaggs School of Pharmacy and Pharmaceutical Sciences


Protease Pathways

IPS - International Proteolysis Society scientists working on all aspects of proteolytic enzymes, their substrates, and inhibitors
MEROPS database peptidase and inhibitor database
UCSD Neuroscience Microscopy Facility at UCSD Fluorescence Cell Imaging

Enzymes: Biochemical Properties

Brenda database

Mass Spectrometry

Principals of Mass Spec Quantitation Principals of Mass Spectrometry quantitation
Scripps Center for MS providing analyses on a broad range of biological species from small molecules to large biological complexes


NCBI - National Center for Biotechnology Information National Center for Biotechnology Information
Agilent - Spectrum Mill Protein and peptide identification software
Thermo Finnigan - SEQUEST Protein and peptide identification software
Matrix Sciences - MASCOT Protein and peptide identification software

Organizations and Education

School of Medicine, UCSD School of Medicine
School of Pharmacy, UCSD School of Pharmacy
Neurosciences, UCSD Neurosciences Department
SFN - Society for Neurosciences Society for Neurosciences
HUPO - Human Proteome Organization Human Proteome Organization
NIH - National Institutes of Health National Institutes of Health

Publications In Press:

Hook, V., Funkelstein, L., Lu, D., Bark, S., Wegrzyn, J., and Hwang, S.-R. (2007) Proteases for processing proneuropeptides into peptide neurotransmitters and hormones. Annu. Rev. Pharmacol. Tox.

Bark, S.J., and Hook, V. (2007) Differentical recovery of peptides from sample tubes and the reproducibility of quantitative proteomic data. J. Proteome Research.


Hook, G., Hook, V.Y.H., and Kindy, M. (2007) Cysteine protease inhibitors reduce brain beta-amyloid and beta-secrease activity in vivo and are potential Alzheimer's disease therapeutics. Biol. Chem. 388, 979-983.

Hwang, S.R., and Hook, V.Y.H. (2007) Multiple domains of endopin 2A for serpin cross-class inhibition of papain. Arch. Biochem. Biophys. 46, 219-224.