University of California, San Diego | Skaggs School of Pharmacy and Pharmaceutical Sciences

Publication List, 2015-2021


Jiang, Z., Lietz, C.B., Podvin, S., Yoon, M.C., Toneff, T., Hook, V., O'Donoghue, A.J. (2021) Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing. ACS Chem Neurosci. 12(13), 2385-2398.

Yoon, M.C., Solania, A., Jiang, Z., Christy, M.P., Podvin, S., Mosier, C., Lietz, C.B., Ito, G., Gerwick, W.H., Wolan, D.W., Hook, G., O'Donoghue, A.J., Hook, V. (2021) Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions. ACS Chem Biol. 16(9), 1628-1643.

Podvin, S., Jones, A., Liu, Q., Aulston, B., Mosier, C., Ames, J., Winston, C., Lietz, C.B., Jiang, Z., O'Donoghue, A.J., Ikezu, T., Rissman, R.A., Yuan, S.H., Hook, V. (2021) Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS Omega 6(20), 13033-13056.

Boyarko, B., Hook, V. (2021) Human tau isoforms and proteolysis for production of toxic tau fragments in neurodegeneration. Frontiers in Neuroscience 15, 1-19.

Campeau, A., Mills, R.H., Stevens, T., Rossitto, L.A., Meehan, M., Dorrestein, P., Daly, R., Nguyen, T.T., Gonzalez, D.J., Jeste, D.V., Hook V. (2021) Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia. Nature Molecular Psychiatry 2021 Nov 5.

Lee, K.C., and Hook, V. (2021) Antipsychotic drugs. In: Comprehensive Textbook of Psychiatry, 11 edition, editor Sadock, B.J., Wolters Kluwer, Philadelphia, PA, in press.

Wang, S., Leem, J.S., Podvin, S., Hook, V., Kleschevnikov, N., Savchenko, P., Dhanani, M., Zhou, K., Kelly, I.C., Zhang, T., Miyanohara, A., Nguyen, P., Kleschevnikov, A., Wagner, S.L., Trojanowski, J.Q., Roth, D.M., Patel, H.H., Patel, P.M., Head, B.P. (2021) Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD. Mol Ther Methods Clin Dev. 21, 434-450.

Mellott, D.M., Tseng, C.T., Drelich, A., Fajtová, P., Chenna, B.C., Kostomiris, D.H., Hsu, J., Zhu, J., Taylor, Z.W., Kocurek, K.I., Tat, V., Katzfuss, A., Li, L., Giardini, M.A., Skinner, D., Hirata, K., Yoon, M.C., Beck, S., Carlin, A.F., Clark, A.E., Beretta, L., Maneval, D., Hook, V., Frueh, F., Hurst, B.L., Wang, H., Raushel, F.M., O'Donoghue, A.J., de Siqueira-Neto, J.L., Meek, T.D., McKerrow, J.H. (2021) A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells. ACS Chem Biol. 6(4), 642-650.

Ashhurst, A.S., Tang, A.H., Fajtová, P., Yoon, M.C., Aggarwal, A., Bedding, M.J., Stoye, A., Beretta, L., Pwee, D., Drelich, A., Skinner, D., Li, L., Meek, T.D., McKerrow, J.H., Hook, V., Tseng, C.T., Larance, M., Turville, S., Gerwick, W.H., O'Donoghue, A.J., Payne, R.J. (2021) Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. J Med Chem. 2021 Nov 3.


Boutté, A.M., Hook, V., Thangavelu, B., Sarkis, G.A., Abbatiello, B.N., Hook, G., Jacobsen, J.S., Robertson, C.S., Gilsdorf, J., Yang, Z., Wang, K.K.W., Shear, D.A. (2020) Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid. J Neurotrauma 37(13), 1574-1586.

Podvin, S., Jones, A., Liu, Q., Aulston, B., Ransom, L., Ames, J., Shen, G., Lietz, C.B., Jiang, Z., O'Donoghue, A.J., Winston, C., Ikezu, T., Rissman, R.A., Yuan, S., Hook, V. (2020) Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics 9, 1017-1034.

Hook, V., Yoon, M., Mosier, C., Ito, G., Podvin, S., Head, B.P., Rissman, R., O'Donoghue, A.J., Hook, G. (2020) Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 1868, 140428.

Jiang, M., Meng, J., Zeng, F., Qing, H., Hook, G., Hook, V., Wu, Z., Ni, J. (2020) Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling. J Neurochem. 155, 300-312.

Maffioli, E., Jiang, Z., Nonnis, S., Negri, A., Romeo, V., Lietz, C.B., Hook, V., Ristagno, G., Baselli, G., Kistler, E.B., Aletti, F., O'Donoghue, A.J., Tedeschi, G. (2020) High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma. Molecules 25(18), 4071.


Podvin, S., Reardon, H.T., Yin, K., Mosier, C., Hook, V. (2019) Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration. J Neurol. 266, 551-564.

Hook, V., Kind, T., Podvin, S., Palazoglu, M., Tran, C., Toneff, T., Samra, S., Lietz, C., Fiehn, O. (2019) Metabolomics Analyses of 14 Classical Neurotransmitters by GC-TOF with LC-MS Illustrates Secretion of 9 Cell-Cell Signaling Molecules from Sympathoadrenal Chromaffin Cells in the Presence of Lithium. ACS Chem Neurosci. 10(3), 1369-1379.

Garrett-Bakelman, F.E., Darshi, M., Green, S.J., Gur, R.C., Lin, L., Macias, B.R., McKenna, M.J., Meydan, C., Mishra, T., Nasrini, J., Piening, B.D., Rizzardi, L.F., Sharma, K., Siamwala, J.H., Taylor, L., Vitaterna, M.H., Afkarian, M., Afshinnekoo, E., Ahadi, S., Ambati, A., Arya, M., Bezdan, D., Callahan, C.M., Chen, S., Choi, A.M.K., Chlipala, G.E., Contrepois, K., Covington, M., Crucian, B.E., De Vivo, I., Dinges, D.F., Ebert, D.J., Feinberg, J.I., Gandara, J.A., George, K.A., Goutsias, J., Grills, G.S., Hargens, A.R., Heer, M., Hillary, R.P., Hoofnagle, A.N., Hook, V.Y.H., Jenkinson, G., Jiang, P., Keshavarzian, A., Laurie, S.S., Lee-McMullen, B., Lumpkins, S.B., MacKay, M., Maienschein-Cline, M.G., Melnick, A.M., Moore, T.M., Nakahira, K., Patel, H.H., Pietrzyk, R., Rao, V., Saito, R., Salins, D.N., Schilling, J.M., Sears, D.D., Sheridan, C.K., Stenger, M.B., Tryggvadotter, .R, Urban, A.E., Vaisar, T., Van Espen, B., Zhang, J., Ziegler, M.G., Zwart, S.R., Charles, J.B., Kundrot, C.E., Scott, G.B.I., Bailey, S.M., Basner M,, Feinberg, A.P., Lee, S.M.C., Mason, C.E., Mignot, E., Rana, B.K., Smith, S.M., Snyder, M.P., Turek, F.W. (2019) The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science 364(6436), eaau8650.

Bibo-Verdugo, B., Wang, S.C., Almaliti, J., Ta, A.P., Jiang, Z., Wong, D.A., Lietz, C.B., Suzuki, B.M., El-Sakkary, N., Hook, V., Salvesen, G.S., Gerwick, W.H., Caffrey, C.R., O'Donoghue, A.J. (2019) The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni. ACS Infect Dis. 5(10), 1802-1812.

Boudreau, P.D., Miller, B.W., McCall, L.I., Almaliti, J., Reher, R., Hirata, K., Le, T., Siqueira-Neto, J.L., Hook, V., Gerwick, W.H,. (2019) Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain. J Med Chem. 62, 9026-9044.


Lietz, C.B., Toneff, T., Mosier, C., Podvin, S., O'Donoghue, A.J., Hook, V. (2018) Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles. J Am Soc Mass Spectrom. 29, 935-947.

Hook, V., Lietz, C.B., Podvin, S., Cajka, T., Fiehn, O. (2018) Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry. J Am Soc Mass Spectrom. 29(5), 807-816.

Podvin, S., Wojnicz, A., Hook, V. (2018) Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production. Heliyon 4, e00673.

Xu, J.H., Jiang, Z., Solania, A., Chatterjee, S., Suzuki, B., Lietz, C.B., Hook, V.Y.H., O'Donoghue, A.J., Wolan, D.W. (2018) A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro. ACS Chem Biol. 13(9), 2513-252.

Hsu, A., Podvin, S., Hook, V. (2018) Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development. J Mol Neurosci. 65(4), 420-431.


Benyamin, B., Maihofer, A.X., Schork, A.J., Hamilton, B.A., Rao, F., Schmid-Schönbein, G.W., Zhang, K., Mahata, M., Stridsberg, M., Schork, N.J., Biswas, N., Hook, V.Y., Wei, Z., Montgomery, G.W., Martin, N.G., Nievergelt, C.M., Whitfield, J.B., O'Connor, D.T. (2017) Identification of novel loci affecting circulating chromogranins and related peptides. Hum Mol Genet. 26, 233-242. PMID: 28011710; PMCID: PMC6075630.

Lee, K.C., and Hook, V. (2017) Treatment of Psychiatric Disorders. In: Comprehensive Textbook of Psychiatry.


Podvin, S., Yaksh, T.L., and Hook, V. (2016) Emerging role of spinal dynorphin in chronic pain, a therapeutic perspective. Invited Review. Annual Review of Pharmacology and Toxicology 56, 511-33.

Petras, D., Nothias, L.F., Quinn, R.A., Alexandrov, T., Bandeira, N., Bouslimani, A., Castro-Falcón, G., Chen, L., Dang, T., Floros, D.J., Hook, V., Garg, N., Hoffner, N., Jiang, Y., Kapono, C.A., Koester, I., Knight, R., Leber, C.A., Ling, T.J., Luzzatto-Knaan, T., McCall, L.I., McGrath, A.P., Meehan, M.J., Merritt, J.K., Mills, R.H., Morton, J., Podvin, S., Protsyuk, I., Purdy, T., Satterfield, K., Searles, S., Shah, S., Shires, S., Steffen, D., White, M., Todoric, J., Tuttle, R., Wojnicz, A., Sapp, V., Vargas, F., Yang, J., Zhang, C., Dorrestein, P.C. (2016) Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats. Anal Chem. 88, 10775-10784.


Hook, V., Podvin, S., Bundey, R., Toneff, T., and Ziegler, M. (2015) Profiles of secreted neuropeptides and catecholamines illustrate similarities and differences in response to stimulation by distinct secretagogues. Molecular and Cellular Neuroscience 68, 177-185.

Hook, G., Jacobsen, J.S., Grabstein, K., Kindy, M., Hook, V. (2015) Cathepsin B is a new drug target for traumatic brain injury therapeutics: evidence for E64d as a promising lead drug candidate. Frontiers Neurology 6, 1-27.

Hook, V., Bandeira, N. (2015) Neuropeptidomics mass spectrometry reveals signaling networks generated by distinct protease pathways in human systems. J. American Society of Mass Spectrometry 26, 1970-80.