Chantal Reed, Ph.D.

Chantal Reed, Ph.D.
Email
careed@health.ucsd.edu
Phone
(858) xxx-xxxx
Research Summary

Chantal Reed, Ph.D., is the course chair for “Dosage Forms and Drug Delivery Systems” in the Skaggs School of Pharmacy and Pharmaceutical Sciences, and holds the position of Health Sciences Assistant Clinical Professor, Non-Salaried.  She is also an independent consultant in Pharmaceutical Development, working with several local biotech and pharma companies.  She specializes in technical report writing, data auditing, experimental design and set up, literature reviews and feasibility study design.  She previously worked at Ionis Pharmaceuticals, in Pharmaceutical Development, where her focus was on pharmaceutical R & D and product quality in the area of drug delivery and product quality for antisense oligonucleotides.  She performed formulation research to qualify new dosage forms appropriate for specific therapeutic indications and routes of administration, including novel (liposomal and polymeric) dosage forms, aseptically prepared parenteral solutions and nasal sprays.  Prior to this, she was responsible for validation of lead oligonucleotides, including optimization of transfection conditions in new and difficult cell types, including primary cells, investigating cell-type specific parameters which affect the efficiency of in vitro transfection, and effectively communicating protocols to corporate partners.

Academic Achievements

Harvard University, B.A. Engineering Sciences, (1996), University of Washington, Ph.D. Bioengineering (1982).

Teaching

Dosage Forms and Drug Delivery Systems, (SPPS 225)

Key Contributions

“NSF IGERT Fellowship Award”, University of Washington Center for Nanotechnology (2000), Merit Based Travel Grant, American Society of Gene Therapy (2000), “Cygnus Graduate Student Award for Outstanding Work in Drug Delivery”, Controlled Release Society (1998),“University Initiative Fund Graduate Fellowship”, University of Washington Center for Nanotechnology (1997).

Selected Publications
  • Slupska, M.M., King, A.G., Lu, L.I., Lin, R.H., Mao, E.F., Lackey, C.A., Chiang, J.H., Baikalov, C., and Miller, J.H. (1998) Examination of the role of DNA polymerase proofreading in the mutator effect of miscoding tRNAs. Journal of Bacteriology. 180(21), 5712-7.
  • Lackey, C. A., Murthy, N., Press, O. W., Tirrell, D. A., Hoffman, A. S., and Stayton, P. S. (1999) Hemolytic Activity of pH-responsive Polymer-Streptavidin Bioconjugates. Bioconjugate Chemistry. 10, 401-5.
  • Stayton, P.S., Hoffman, A.S., Murthy, N., Lackey, C., Cheung, C., Tan, P., Klumb, L.A., Chilkoti, A., Wilbur, F.S., and Press, O.W. (2000) Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics. Journal of Controlled Release. 65(1-2), 203-20.
  • Hoffman A. S., Stayton P. S., Bulmus V., Chen G., Chen J., Cheung C., Chilkoti A., Ding Z., Dong L., Fong R., Lackey C. A., Long C. J., Miura M., Morris J. E., Murthy N., Nabeshima Y., Park T. G., Press O. W., Shimoboji T., Shoemaker S., Yang H. J., Monji N., Nowinski R. C., Cole C. A., Priest J. H., Harris J. M. (2000) Really Smart Bioconjugates Of Smart Polymers And Receptor Proteins. Journal of Biomedical Materials Research. 52(4), 577-86.
  • Lackey, C. A., Press, O. W., Hoffman, A. S., and Stayton, P. S. (2002) A Biomimetic pH-Responsive Polymer Directs Endosomal Release and Intracellular Delivery of an Endocytosed Antibody Complex.  Bioconjugate Chemistry, 13(5), 996-1001.
  • Liang, Y., Osborne, M. C., Monia, B. P., Bhanot, S., Gaarde, W. A., Reed, C., She, P., Jetton, T. L., and Demarest, K. T. (2003) Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice.  Diabetes. 53(2), 410-7.
  • Lackey, C. A., Murthy, N., Stayton, P. S., Press, O. W., Hoffman, A. S. and Tirrell, D. A. (1998) Stimuli-Responsive Biomolecular Conjugates:  Controlled Membrane Disruption.  Controlled Release Society International Symposium.  Las Vegas, NE.  June 21-24.
  • Lackey, C. A., Press, O. W., Hoffman, A. S., and Stayton, P. S. (2000) Enhancement of Cell Transfection Efficiency by a Biomimetic Membrane-Disruptive Polymer in a Model Nonviral, Targeted Delivery System.  American Society of Gene Therapy National Meeting.  Denver, CO.  May 31-June 4.
  • Lackey, C. A., Press, O. W., Hoffman, A. S., and Stayton, P. S. (2000) Enhancement of Cell Transfection Efficiency by a Biomimetic Membrane-Disruptive Polymer in a Model Nonviral, Targeted Delivery System.  Biomedical Engineering Society Annual Meeting.  Seattle, WA.  October 12-14.