Dr. David Gonzalez

Host Microbe-Interaction

David Gongalez Photo
David J. Gonzalez, Ph.D.

Assistant Professor
Skaggs School of Pharmacy and Pharmaceutical Sciences
Department of Pharmacology, School of Medicine

Founder and Director for the Collaborative Center of Multiplexing Proteomics

Email
djgonzalez@ucsd.edu
Phone
(858) 822-1218
Research Summary

My laboratory aims to study the biochemistry that governs host-microbe interactions. From a systems scale to single target approach, we focus on studying bacterial pathogenesis, host responses to infection, and the impact of the microbiome on health and disease. At its core, the laboratory develops and applies multiplexing quantitative proteomics tools to simultaneously track thousands of protein dynamics and associated post-translational modifications in an accurate and high throughput fashion. We then interface microbiology techniques to characterize important factors identified during these interactions. When appropriate, translational studies of therapeutic value are undertaken in tissue culture, murine models, and by the analysis of human biospecimens. This information is then used to design novel strategies for the detection or treatment of microbial-driven infectious diseases in humans.

Academic Achievements

Education:

B.A. in Chemistry (2006) California State University, San Marcos; Ph.D. (2011) University of California, San Diego; Postdoctoral Fellow (2011-2014) University of California San Diego.

Awards and Honors:

Keystone Symposium Fellow (2019), UC President’s Postdoctoral Award (2014), IRACDA UCSD Fellowship (2013), A.P. Giannini Medical Fellow (2011), AGEP Fellow (2006), Competitive-edge Predoctoral Award (2006), UCSD STARS Program (2005).

Leadership Experience:

Biomedical Sciences Graduate Admission Underrepresented Minority Coordinator (2016-2019), Yale Bouchet Honor Society Inductee for excellent research and commitment to diversity and equality (2010).

Key Contributions
  • Development of mass spectrometry tools to study specialized molecules important to the host-microbe interaction.
  • Elucidated mechanisms used by multidrug resistant Staphylococcus aureus to clear host microbiome.
Potential Collaborative Programs
  • Multiplexed quantitative proteomics, metabolomics, and posttranslational modification characterization (e.g. phosphoproteomics)
  • Identifying and characterizing virulence mechanisms and host responses as therapeutic targets in leading microbial pathogens. 
  • Specialized proteomics tools for the analysis of fecal and tissue samples associated with the human microbiome.
  • Advanced biomarker discovery analysis that includes the identification of disease specific posttranslational modifications.