Clinical Pharmacology and Pain Management
Professor of Clinical Pharmacy
Skaggs School of Pharmacy and Pharmaceutical Sciences
Dr. Ma’s research interests are in examining methods that evaluate drug-drug interactions. His research has elucidated that several methods estimating in vivo, real-time, drug-metabolizing enzyme activity are inadequate and lack optimal validation. Dr. Ma is also interested in examining pain medication pharmacokinetic and pharmacodynamic variability in opioid-treated, cancer patients.
Dr. Ma's clinical practice is in pain and palliative care in an outpatient, multidisciplinary clinic at the Moores Cancer Center. Under a collaborative practice protocol, Dr. Ma sees patients and is able to start, stop, or modify therapy to treat symptoms and sides effects of a disease and its treatment.
Education: B.S. Biology, UC Irvine (1998); Pharm.D., UC San Francisco (2002); Fellowship Clinical Pharmacology/Drug Metabolism, Bassett Healthcare, Cooperstown, NY (2002-2004).
Awards and Honors: NIDA Intramural Research Training Award, NIH (1997, 1998); UC San Diego SSPPS Faculty Teaching Award (2008, 2013, 2017); Fellow Clinical Pharmacology, American College of Clinical Pharmacology (2015); Excellence in Achievement, American College of Clinical Pharmacology (2016).
Leadership Experience: Clinical Trial Associate, Early Development, Amgen, Inc. (2004-2007); Meeting Program Committee Member, ACCP Annual Meeting, San Antonio, TX, (2009); Co-chair, Symposium: Innovations and Controversies in Quantifying Drug-Drug Interactions, ACCP Annual Meeting, San Antonio, TX, (2009), Meeting Program Co-chair, ACCP Annual Meeting, San Diego, CA (2012).
- Pharmacogenomics (SPPS219)
- Pharmacy Therapeutics (SPPS 212B/D)
- Master’s Program in Drug Development and Product Management (DDPM)
- Evaluated accuracy and validity of in vivo cytochrome P450 (CYP) and P-glycoprotein phenotyping methods and probe drugs.
- Serving as co-Director for Master’s Program in Drug Development and Product Management (DDPM).
- Clinical research in in vivo phenotyping studies, methodology evaluation, and utility of limited sampling strategies.
- Yang et al. (2019) Midazolam limited sampling strategy with a population pharmacokinetic approach to simultaneously estimate cytochrome P450 (CYP) 3A constitutive, inhibition, and induction/activation conditions in healthy adults. Journal of Clinical Pharmacology 59(11):1495-1504
- Roeland et al. (2020) More opioids, more constipation? Evaluation of longitudinal total oral opioid consumption and self-reported constipation in patients with cancer. Supportive Care in Cancer 28(4): 1793-1797.
- Jarmusch et al. (2020) Enhanced Characterization of Drug Metabolism and Influence of the Microbiome: a Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. Clinical and Translational Science 13:972-984.
- Ma et al. (2021) Exploring the expanded role of pharmacists in advance care planning. JCO Oncology Practice 17(2): 102-106.
- Tran et al. (2021) S-warfarin limited sampling strategy with a population pharmacokinetic approach to estimate exposure and cytochrome P450 (CYP) 2C9 activity in healthy adults. European Journal of Clinical Pharmacology 77(9): 1349-1356.
- Experience in private and public sector in clinical
trial operations, management, and execution.
- Experience in Proof of concept, phase I (FIH), and drug-drug interaction studies.
- Developing novel teaching methods for health care professionals encompassing areas of drug discovery, development, and commercialization.