Transcription, Epigenetics, DNA Damage and Repair, Chemotherapy
Skaggs School of Pharmacy and Pharmaceutical Sciences
Dr. Wang’s research focuses on understanding transcription and epigenetic regulation, chromatin dynamics, DNA damage repair, as well as developing novel anticancer drugs.
Dr. Wang’s group takes a multidisciplinary approach, combining structural biology, chemical biology, biochemistry, computational biology, and genetic methods, to study key protein complexes involved in these fundamental processes and pathways. Understanding how cell process these DNA lesions will help us to understand the mechanisms of drug action and resistance and pave the way for rational improvement of novel anticancer drugs.
B.Sc. in Chemistry (1998) Peking University; Ph. D. in Biological Chemistry (2004) Massachusetts Institute of T echnology; Postdoc Fellow in Structural Biology at Stanford University School of Medicine (2009).
Awards and Honors:
OKeanos-CAPA Young Investigator Award at the Chemical and Biology Interface (2015); Kimmel Scholar Award (2012); UCSD Academic Senate Research Grant Award (2010); CIBA Young Scientist Award (2010); NIH Pathway to Independence Award (K99/R00, 2008); Leukemia & Lymphoma Society Career Development Program Special Fellow Award (2007); ASBMB Travel Award (2007&2008); ASBMB Chromosome Cycle Theme Poster Award (2007); Anna Fuller Fund Graduate Fellowship (2002).
Executive committee member, Stanford University Postdoc Association (2007-2008); Executive council member, Chinese-American Biopharmaceutical Society (2007-2008); Co-Chair, Chinese Life Sciences Postdocs and Students at Stanford (2005-2007).
- Pharmaceutical Chemistry I (SPPS 221)
- Pharmaceutical Chemistry III (SPPS 223)
- Concepts in Pharmacy Practice (SSPPS 202A)
- CTIPS (SPPS218B)
- Macromolecular Recognition (Chem 209)
- Chemical Biology (Chem 216)
- Investigate the action and resistance mechanisms of platinum anticancer agents.
- Structural studies of transcription inhibition by a variety of anticancer agents.
- Wang D et al. (2006). Structural basis of transcription: Role of the trigger loop in substrate specificity and catalysis. Cell 127:941-954.
- Wang et al. (2009). Structural basis of transcription: Backtracked RNA polymerase II at 3.4 Å resolution. Science 324:1203-1206
- Wang D et al. (2010). X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct. Proc. Natl. Acad. Sci. USA, 107:9584-9589.
- Kellinger M.W. et al. (2012). • 5-Formyl- and 5-carboxyl- cytosine reduce the rate and substrate specificity of RNA polymerase II transcription. . Nature Struct. Mol. Biol.19:831-833.
- Walmacq C et al. (2015) Mechanism of RNA Polymerase II Bypass of Oxidative Cyclopurine DNA Lesions. Proc. Natl. Acad. Sci. USA 112(5), E410-419.
- Wang L et al. (2015) Molecular Basis for 5 Carbonxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621-625.
- Xu et al. (2016). ) RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif. . Proc. Natl. Acad. Sci. USA 113(44):12426-12431.
- Xu et al (2017). Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. 551:653-657.