Dr. Eduardo S. Fricovsky, Pharm.D.
Health Sciences Clinical Professor of Pharmacy
Skaggs School of Pharmacy and Pharmaceutical Sciences
Dr. Fricovsky’s research interest includes diabetic cardiomyopathy and the effects of enzymatic protein glycosylation (O-GlcNAc) in type 2 diabetic mouse hearts and their influence on cardiac function. Also, conducts studies related to the expression of O-GlcNAcase (GCA) an enzyme that removes excessive O-GlcNAc modification and protection against diabetic cardiomyopathy. Furthermore, he examines the role of GCA gene expression and O- GlcNAc levels in non-diabetics and diabetic patients at the UC San Diego Student-Run Free Clinic.
Education: B.S. in Biochemistry/Chemistry (2002) UC San Diego; UCSF School of Pharmacy (2006); NIH T32 Research Fellow (2006-2009) UC San Diego, Department of Medicine.
Awards and Honors: ASHP Outstanding Professional Development Project Award (2014); American Pharmacy Association National Immunization Champion Award (2014); UC San Diego Student Run Free Clinics Community Leadership Award (2013); UC San Diego Health Science Academic Senate Research Award (2012) UC San Diego Student Run Free Clinic Angel Award (2012); Society of Chemical Industry Teacher Award (2011); UC San Diego Skaggs School of Pharmacy Excellence in Teaching Award (2009-2010); UC San Diego Student Run Free Clinic Project Clinical Leader Award (2009); UC San Diego Student Run Free Clinic Project Pharmacy Faculty Leader Award (2008).
Leadership Experience: Founder and President of the UCSF Latino Association of Pharmacy Students (LAPS) (2003- 2005); UC San Diego Student Run Free Clinic Project Pharmacy Director (2009-Present); AdHoc SSPPS Non-Salary Faculty Review Committee (2009- Present); Co-Chair SSPPS ACTION Academic Communities (2010-Present); UC San Diego OASIS Alumni Committee Officer (2012-Present)
- Pharmacy Therapeutics (SPPS 212A).
- Pharmacy Practice (SPPS 201, 202, 203).
- Pharmacy Preceptor: UC San Diego Student-Run Free Clinic Project (IPPE & APPE).
- Suarez et al. (2008). Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardio-myocytes. Am J Physiol Cell Physiol. 295:C1561-C1568.
- *Romero-Perez et al. (2008). Cardiac uptake of minocycline and mechanisms for in vivo cardioprotection. J Am Col Cardiol. 52:1086-1094.
* Shared first co-First Author. - Hu et al. (2009). Increased enzymatic O- GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose. J Biol Chem. 284:547-555.
- Griffin et al. (2010). Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature.Am J Physiol Cell Physiol.
- Fricovsky et al. (2012). Excess protein O- GlcNAcylation and the progression of diabetic cardiomyopathy. Am J Physiol Regul Integr Comp Physiol. 303:R689-99
- Suarez et al. (2013). Sorcin modulates mitochondrial Ca2+ handling and reduces apoptosis in neonatal rat cardiac myocytes. Am J Physiol Cell Physiol. 304:C248-56.
- *Aguilar et al. (2014). Role for high glucose induced protein O-GlcNAcylation in stimulating cardiac fibroblast collagen synthesis.Am J Physiol Cell Physiol. 306(9):C794-804.
* Shared first co-First Author.